Transmembrane protein 108 is required for glutamatergic transmission in dentate gyrus
Copyright policy )Transmembrane protein 108 is required for glutamatergic transmission in dentate gyrus
SignificanceDentate gyrus (DG) dysfunction has been implicated in schizophrenia, a disabling psychiatric disorder. However, underlying pathophysiological mechanisms are not clear. We provide evidence that Tmem108, a novel schizophrenia-associated gene, is highly enriched in DG granule neurons. Tmem108 is required for spine development and glutamatergic transmission. Further investigations indicate a critical role of Tmem108 for AMPA receptor expression in postsynaptic compartments. Mutation ofTmem108leads to schizophrenia-related behavioral deficits. These results provide insight into a potential pathophysiological mechanism for DG dysfunction in schizophrenia.
- Nanchang University China (People's Republic of)
- University System of Georgia United States
- Nanchang University China (People's Republic of)
- Georgia Regents University United States
- Augusta University United States
Male, Mice, Knockout, Neurons, Excitatory Postsynaptic Potentials, Glutamic Acid, Post-Synaptic Density, Fear, Disease Models, Animal, Mice, Electroporation, HEK293 Cells, Animals, Newborn, Genes, Reporter, Dentate Gyrus, Animals, Humans, RNA Interference, RNA, Small Interfering, Cognition Disorders, Maze Learning
Male, Mice, Knockout, Neurons, Excitatory Postsynaptic Potentials, Glutamic Acid, Post-Synaptic Density, Fear, Disease Models, Animal, Mice, Electroporation, HEK293 Cells, Animals, Newborn, Genes, Reporter, Dentate Gyrus, Animals, Humans, RNA Interference, RNA, Small Interfering, Cognition Disorders, Maze Learning
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