Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations
Copyright policy )Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations
Key Points Whole-exome sequencing of CLL patients who relapsed after FCR treatment revealed frequent mutations in RPS15. RPS15 mutations are likely to be early clonal events and confer poor prognosis.
- University of Padua Italy
- Erasmus University Medical Center Netherlands
- National and Kapodistrian University of Athens Greece
- Lund University Sweden
- NIHR Biomedical Research Centre at The Royal Marsden and the ICR United Kingdom
Ribosomal Proteins, Blotting, Western, DNA Mutational Analysis, Mutation, Missense, 610, Cell Separation, Kaplan-Meier Estimate, Transfection, Leukemia, Lymphocytic, Chronic, B-Cell, EMC MM-02-72-01, Drug Resistance, Neoplasm, Antineoplastic Combined Chemotherapy Protocols, Humans, Immunoprecipitation, Exome, Neoplasm Recurrence, Local, Tumor Suppressor Protein p53, Rituximab, Cyclophosphamide, Vidarabine
Ribosomal Proteins, Blotting, Western, DNA Mutational Analysis, Mutation, Missense, 610, Cell Separation, Kaplan-Meier Estimate, Transfection, Leukemia, Lymphocytic, Chronic, B-Cell, EMC MM-02-72-01, Drug Resistance, Neoplasm, Antineoplastic Combined Chemotherapy Protocols, Humans, Immunoprecipitation, Exome, Neoplasm Recurrence, Local, Tumor Suppressor Protein p53, Rituximab, Cyclophosphamide, Vidarabine
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