Structure of the large ribosomal subunit from human mitochondria
Copyright policy )Structure of the large ribosomal subunit from human mitochondria
Making mitochondrial hydrophobic proteins Mitochondria produce chemical energy for the cell. Human mitochondria have their own specific ribosomes—mitoribosomes, which are distinct from cytoplasmic ribosomes. Mitoribosomes synthesize the mitochondrial membrane proteins that generate the chemical energy. Brown et al. used cryo–electron microscopy to determine the high-resolution structure of the large subunit of the human mitoribosome. The mitoribosome has a number of unique features, including an exit tunnel lined with hydrophobic amino acid residues. Science , this issue p. 718
- Medical Research Council United Kingdom
- MRC Laboratory of Molecular Biology United Kingdom
Mitochondrial Proteins, Binding Sites, Protein Conformation, Cryoelectron Microscopy, Mutation, Ribosome Subunits, Humans, Nucleic Acid Conformation, RNA, Transfer, Val, Mitochondria
Mitochondrial Proteins, Binding Sites, Protein Conformation, Cryoelectron Microscopy, Mutation, Ribosome Subunits, Humans, Nucleic Acid Conformation, RNA, Transfer, Val, Mitochondria
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