Calliandra estebanensis, a new species of Fabaceae, mimosoid, from a remote locality of Sinaloa, Mexico, is here described and illustrated. The new species is probably closely related to C. grandiflora, an extremely common species frequently found in oak, pine and pine-oak forests, from northwestern Mexico, in Durango, Sinaloa and Sonora, to Honduras and El Salvador. The new species is distinguished from C. grandiflora by its flowers with longer peduncles, shorter pedicels, and larger calyces and corollas, and by the much denser white-sericeous vestiture covering all reproductive structures. Excluding the longer pedicels, C. grandiflora has smaller flower parts, which are covered with a finer vestiture of shorter, variably-colored trichomes.