Cloning and expression pattern of a zebrafish homolog of forkhead activin signal transducer (FAST), a transcription factor mediating Nodal-related signals
Copyright policy )Cloning and expression pattern of a zebrafish homolog of forkhead activin signal transducer (FAST), a transcription factor mediating Nodal-related signals
Forkhead activin signal transducer (FAST) is a member of the winged-helix family of DNA-binding proteins that has been implicated in mesoderm induction and left-right axis specification during embryonic development in Xenopus and mouse. We have cloned and characterized a zebrafish FAST homolog. Zebrafish fast is expressed maternally and zygotically. Transcripts start regionalizing and decline in level during gastrulation. During somitogenesis, fast is expressed bilaterally in the lateral plate mesoderm, like its mouse homolog. In addition, zebrafish fast is also expressed bilaterally in the dorsal diencephalon, where the nodal-related cyclops gene is only expressed on the left side. It remains to be demonstrated whether FAST expression in the brain can mediate Nodal-induced asymmetric development.
- University of Milan Italy
- Max Planck Society Germany
- Max Planck Institute for Developmental Biology Germany
- University of Padua Italy
Embryology, DNA, Complementary, Time Factors, Sequence Homology, Amino Acid, Molecular Sequence Data, Brain, Forkhead Transcription Factors, DNA-Binding Proteins, Mesoderm, Somites, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, In Situ Hybridization, Zebrafish, forkhead activin signal transducer; maternal genes; activin; Nodal; cyc; oep; left-right asymmetry; brain; epithalamus; habenula; winged helix; forkhead domain; Smad, Developmental Biology, Transcription Factors
Embryology, DNA, Complementary, Time Factors, Sequence Homology, Amino Acid, Molecular Sequence Data, Brain, Forkhead Transcription Factors, DNA-Binding Proteins, Mesoderm, Somites, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, In Situ Hybridization, Zebrafish, forkhead activin signal transducer; maternal genes; activin; Nodal; cyc; oep; left-right asymmetry; brain; epithalamus; habenula; winged helix; forkhead domain; Smad, Developmental Biology, Transcription Factors
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