Mice deficient for the IL-3/GM-CSF/IL-5 βc receptor exhibit lung pathology and impaired immune response, while βIL3 receptor-deficient mice are normal
Copyright policy )Mice deficient for the IL-3/GM-CSF/IL-5 βc receptor exhibit lung pathology and impaired immune response, while βIL3 receptor-deficient mice are normal
The receptors for IL-3, GM-CSF, and IL-5 share a common beta subunit (beta c), and mice have an additional IL-3 beta subunit (beta IL3). We have independently generated mice carrying null mutations of each molecule. beta c mutant bone marrow showed no response to GM-CSF or IL-5, whereas IL-3 stimulation of beta c or beta IL3 mutant bone marrow was normal. beta c mutant mice showed lung pathology consisting of lymphocytic infiltration and areas resembling alveolar proteinosis, and also exhibited low basal numbers of eosinophils. Infection of beta c mutant mice by Nippostrongylus brasiliensis resulted in the absence of blood and lung eosinophilia. Animals repopulated with beta c mutant bone marrow cells showed slower leukocyte recovery and reduced eosinophil numbers. These data define the role of beta c in vivo, and show a phenotype that is likely to be the cumulative effect of loss of GM-CSF and IL-5 stimulation.
- Yokohama City University Japan
- Tokyo University of Science Japan
- University of Tokyo Japan
Lung Diseases, Mice, Knockout, Base Sequence, Immunology, Molecular Sequence Data, Receptors, Interleukin, Flow Cytometry, Receptors, Interleukin-5, Receptors, Interleukin-3, Eosinophils, Mice, Infectious Diseases, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Immunology and Allergy, Animals, Nippostrongylus, Receptors, Cytokine, Bone Marrow Transplantation, Strongylida Infections
Lung Diseases, Mice, Knockout, Base Sequence, Immunology, Molecular Sequence Data, Receptors, Interleukin, Flow Cytometry, Receptors, Interleukin-5, Receptors, Interleukin-3, Eosinophils, Mice, Infectious Diseases, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Immunology and Allergy, Animals, Nippostrongylus, Receptors, Cytokine, Bone Marrow Transplantation, Strongylida Infections
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