Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex
Copyright policy )Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex
Drosophila telomeres are elongated by transposition of specialized retroelements rather than telomerase activity, and are assembled independently of the terminal DNA sequence. Drosophila telomeres are protected by terminin, a complex that includes the HOAP (Heterochromatin Protein 1/origin recognition complex-associated protein) and Moi (Modigliani) proteins and shares the properties of human shelterin. Here we show that Verrocchio (Ver), an oligonucleotide/oligosaccharide-binding (OB) fold-containing protein related to Rpa2/Stn1, interacts physically with HOAP and Moi, is enriched only at telomeres, and prevents telomere fusion. These results indicate that Ver is a new terminin component; we speculate that, concomitant with telomerase loss, Drosophila evolved terminin to bind chromosome ends independently of the DNA sequence.
Models, Molecular, Protein Folding, Chromosomal Proteins, Non-Histone, Telomere-Binding Proteins, Nuclear Proteins, Telomere, Protein Structure, Tertiary, Drosophila melanogaster, Gene Expression Regulation, Mutation, protein folding; protein structure; mutation; terminin; gene expression regulation; genetics/metabolism; chemistry/genetics/isolation /&/ purification/metabolism; tertiary; nuclear proteins; drosophila melanogaster; drosophila proteins; non-histone; telomeres; animals; drosophila; metabolism; chromosomal proteins; telomere; verrocchio; molecular; models; genetics; rpa2/stn1; protein binding; amino acid sequence; sequence alignment; telomere-binding proteins, Animals, Drosophila Proteins, Amino Acid Sequence, Sequence Alignment, Protein Binding
Models, Molecular, Protein Folding, Chromosomal Proteins, Non-Histone, Telomere-Binding Proteins, Nuclear Proteins, Telomere, Protein Structure, Tertiary, Drosophila melanogaster, Gene Expression Regulation, Mutation, protein folding; protein structure; mutation; terminin; gene expression regulation; genetics/metabolism; chemistry/genetics/isolation /&/ purification/metabolism; tertiary; nuclear proteins; drosophila melanogaster; drosophila proteins; non-histone; telomeres; animals; drosophila; metabolism; chromosomal proteins; telomere; verrocchio; molecular; models; genetics; rpa2/stn1; protein binding; amino acid sequence; sequence alignment; telomere-binding proteins, Animals, Drosophila Proteins, Amino Acid Sequence, Sequence Alignment, Protein Binding
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