Expression and characterization of recombinant Japanese encephalitis virus NS1 protein in Drosophila S2 cell
Copyright policy ) Li, Yize; Flamand, Marie; Counor, Dorian; Kieffer, Nelly; Rey, Felix; Deubel, Vincent;
Expression and characterization of recombinant Japanese encephalitis virus NS1 protein in Drosophila S2 cell
Background Japanese encephalitis virus (JEV) is a member of the genus Flavivirus, family Flaviviridae. Flavivirus NS1 glycoproteins are essential proteins, which exhibit a high degree of sequence homology. The NS1 protein is secreted from infected cells as a soluble hexamer and can induce protective immune response in mice against lethal encephalitis. However, its role in neuroinvasion of JEV remains unknown. Our aim is to identify the role of NS1 protein in JEV neuropathogenesis. In this study, we have produced recombinant JEV NS1 protein in Drosophila S2 cells and have characterized its biochemical, biological and antigenic properties.
- INSTITUT PASTEUR (BP) France
- Institut Pasteur France
- Institut Pasteur of Shanghai China (People's Republic of)
- Chinese Academy of Science (中国科学院) China (People's Republic of)
- INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES China (People's Republic of)
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citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 0
Average
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