Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma
Copyright policy )Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma
Improved viral enrichment methods conclusively demonstrate EBV type 1 to be more prevalent in eBL patients than in geographically matched healthy controls, which previously underrepresented the prevalence of EBV type 2. Genome-wide association analysis between cases and controls identifies six eBL-associated nonsynonymous variants in EBNA1, EBNA2, BcLF1, and BARF1 genes. Analysis of population structure reveals that EBV type 2 exists as two genomic subgroups and was more commonly found in female than in male eBL patients.
- Brown University United States
- Ministry of Health Kenya
- Kenya Medical Research Institute Kenya
- Duke University School of Medicine United States
- Duke University School of Medicine United States
Male, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Adolescent, Receptor, Macrophage Colony-Stimulating Factor, Genome, Viral, Pediatrics, Viral Proteins, Hemic and Lymphatic Diseases, Neoplasms, Virology, Odds Ratio, Epstein-Barr virus, Humans, EBV type 2, endemic Burkitt lymphoma, UMCCTS funding, EBV type 1, Child, Translational Medical Research, Population Biology, Genetic Variation, Infant, Genetics and Genomics, Sequence Analysis, DNA, Burkitt Lymphoma, Kenya, genome sequencing, Epstein-Barr Virus Nuclear Antigens, Child, Preschool, genetic variation, Viruses, DNA, Viral, Female, Genetic Phenomena, Genome-Wide Association Study
Male, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Adolescent, Receptor, Macrophage Colony-Stimulating Factor, Genome, Viral, Pediatrics, Viral Proteins, Hemic and Lymphatic Diseases, Neoplasms, Virology, Odds Ratio, Epstein-Barr virus, Humans, EBV type 2, endemic Burkitt lymphoma, UMCCTS funding, EBV type 1, Child, Translational Medical Research, Population Biology, Genetic Variation, Infant, Genetics and Genomics, Sequence Analysis, DNA, Burkitt Lymphoma, Kenya, genome sequencing, Epstein-Barr Virus Nuclear Antigens, Child, Preschool, genetic variation, Viruses, DNA, Viral, Female, Genetic Phenomena, Genome-Wide Association Study
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