The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans
Copyright policy )The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans
In this study, the variable number tandem repeats (VNTR) polymorphism of a 48-bp sequence located in exon 3 of the dopamine receptor D4 (DRD4) gene was genotyped in 365 alcoholic and 337 non-alcoholic Mexican Americans. Logistic regression showed that genotypes without the 7-repeat allele were risk factors for alcoholism. However, linear regression did not find an association between DRD4 VNTR and MAXDRINKS, which was defined as the maximum number of drinks consumed within 24h. Our results indicate the presence of an association between DRD4 VNTR and alcoholism in Mexican Americans.
- University of Kansas United States
- Guangzhou First People's Hospital China (People's Republic of)
- Guangzhou Medical University China (People's Republic of)
- University of Kansas Medical Center United States
Adult, Male, Polymorphism, Genetic, Genotype, Receptors, Dopamine D4, Exons, Minisatellite Repeats, Middle Aged, Alcoholism, Logistic Models, Gene Frequency, Mexican Americans, Humans, Female
Adult, Male, Polymorphism, Genetic, Genotype, Receptors, Dopamine D4, Exons, Minisatellite Repeats, Middle Aged, Alcoholism, Logistic Models, Gene Frequency, Mexican Americans, Humans, Female
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