CD8 T Cell-Specific Downregulation of Histone Hyperacetylation and Gene Activation of the IL-4 Gene Locus by ROG, Repressor of GATA
Copyright policy )CD8 T Cell-Specific Downregulation of Histone Hyperacetylation and Gene Activation of the IL-4 Gene Locus by ROG, Repressor of GATA
Chromatin remodeling of type 2 cytokine gene loci occurs during differentiation of naive CD4 and CD8 T cells into type 2 helper (Th2) and cytotoxic (Tc2) T cells. IL-4 production and histone hyperacetylation in IL-4-associated nucleosomes in developing Tc2 cells were significantly lower than those of Th2 cells; however, cytokine production and histone hyperacetylation of IL-5 and IL-13 genes were equivalent. Developing Tc2 cells expressed lower GATA3 levels and dramatically increased levels of repressor of GATA (ROG). A ROG response element in the IL-13 gene exon 4 displayed Tc2-specific binding of ROG, HDAC1, and HDAC2 and exhibited repression of IL-4 gene activation. Thus, ROG may confer CD8 T cell-specific repression of histone hyperacetylation and activation of the IL-4 gene locus.
- National Presto Industries United States
- Chiba University Japan
Mice, Knockout, Mice, Inbred BALB C, Interleukin-13, Base Sequence, MAP Kinase Signaling System, Calcineurin, Immunology, Down-Regulation, Acetylation, Cell Differentiation, DNA, GATA3 Transcription Factor, CD8-Positive T-Lymphocytes, DNA-Binding Proteins, Histones, Mice, Inbred C57BL, Mice, Infectious Diseases, Gene Expression Regulation, Immunology and Allergy, Animals, Interleukin-4, Cell Division
Mice, Knockout, Mice, Inbred BALB C, Interleukin-13, Base Sequence, MAP Kinase Signaling System, Calcineurin, Immunology, Down-Regulation, Acetylation, Cell Differentiation, DNA, GATA3 Transcription Factor, CD8-Positive T-Lymphocytes, DNA-Binding Proteins, Histones, Mice, Inbred C57BL, Mice, Infectious Diseases, Gene Expression Regulation, Immunology and Allergy, Animals, Interleukin-4, Cell Division
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