Inhibition of the lymphotoxin pathway as a therapy for autoimmune disease
Copyright policy )Inhibition of the lymphotoxin pathway as a therapy for autoimmune disease
Summary: The lymphotoxin (LT) system is part of the tumor necrosis factor family and is required for lymph node development. It has provided a wonderful tool for the dissection of processes critical not only for lymphoid organ development but also the maintenance of the adult immune architecture and the formation of ectopic organized lymphoid tissues in chronically inflamed sites. A soluble lymphotoxin‐β receptor‐immunoglobulin (LTβR‐Ig) fusion protein can block this pathway and is currently being tested in the treatment of autoimmune disease. This review focuses on the immunological consequences of combined LT and LIGHT inhibition with LTβR‐Ig administration as distinct from the developmental biology.
- Biogen (United States) United States
Clinical Trials as Topic, Lymphoid Tissue, Recombinant Fusion Proteins, Lymphotoxin alpha1, beta2 Heterotrimer, Models, Immunological, Cell Differentiation, Autoimmune Diseases, Cell Movement, Lymphotoxin beta Receptor, Animals, Humans, Lymphocytes, Chemokines, Stromal Cells, Signal Transduction
Clinical Trials as Topic, Lymphoid Tissue, Recombinant Fusion Proteins, Lymphotoxin alpha1, beta2 Heterotrimer, Models, Immunological, Cell Differentiation, Autoimmune Diseases, Cell Movement, Lymphotoxin beta Receptor, Animals, Humans, Lymphocytes, Chemokines, Stromal Cells, Signal Transduction
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