MiR‐219‐5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican‐3
Copyright policy )MiR‐219‐5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican‐3
MicroRNAs (miRNAs) have been linked to the molecular pathogenesis of many cancers. In this study, we found that miR‐219‐5p was significantly downregulated in 83 HCC tissues and three HCC cell lines, compared to their non‐tumor counterparts. MiR‐219‐5p expression correlated with tumor size, histological differentiation, and overall survival time in HCC patients. We also found that miR‐219‐5p could inhibit cell proliferation in vitro and arrest cell cycle at the G1 to S transition. Further studies identified that miR‐219‐5p reduced both the mRNA and protein levels of glypican‐3 (GPC3). These findings indicate that miR‐219‐5p exerts tumor‐suppressive effects in hepatic carcinogenesis through negative regulation of GPC3 expression.
- Guangzhou Chest Hospital China (People's Republic of)
- Southern Medical University China (People's Republic of)
- First Affiliated Hospital of Shantou University Medical College China (People's Republic of)
- Shantou University China (People's Republic of)
- Third Affiliated Hospital of Southern Medical University China (People's Republic of)
Male, Carcinoma, Hepatocellular, miR-219-5p, Hepatocellular carcinoma, Cell Cycle, Liver Neoplasms, Down-Regulation, Middle Aged, Gene Expression Regulation, Neoplastic, Survival Rate, MicroRNAs, Glypicans, Cell Line, Tumor, Humans, Female, Glypican-3, Cell proliferation, miRNA, Cell Proliferation
Male, Carcinoma, Hepatocellular, miR-219-5p, Hepatocellular carcinoma, Cell Cycle, Liver Neoplasms, Down-Regulation, Middle Aged, Gene Expression Regulation, Neoplastic, Survival Rate, MicroRNAs, Glypicans, Cell Line, Tumor, Humans, Female, Glypican-3, Cell proliferation, miRNA, Cell Proliferation
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