Mission CaMKIIγ: Shuttle Calmodulin from Membrane to Nucleus
Copyright policy )Mission CaMKIIγ: Shuttle Calmodulin from Membrane to Nucleus
Neuronal plasticity depends on plasma membrane Ca(2+) influx, resulting in activity-dependent gene transcription. Calmodulin (CaM) activated by Ca(2+) initiates the nuclear events, but how CaM makes its way to the nucleus has remained elusive. Ma et al. now show that CaMKIIγ transports CaM from cell surface Ca(2+) channels to the nucleus.
- University of California, Davis United States
- University of California, San Francisco United States
570, Biomedical and clinical sciences, Biomedical and Clinical Sciences, Biochemistry, Genetics and Molecular Biology(all), 1.1 Normal biological development and functioning, Medical Physiology, 500, Biological Sciences, Medical and Health Sciences, Biological sciences, Animals, Generic health relevance, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Cyclic AMP Response Element-Binding Protein, Developmental Biology
570, Biomedical and clinical sciences, Biomedical and Clinical Sciences, Biochemistry, Genetics and Molecular Biology(all), 1.1 Normal biological development and functioning, Medical Physiology, 500, Biological Sciences, Medical and Health Sciences, Biological sciences, Animals, Generic health relevance, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Cyclic AMP Response Element-Binding Protein, Developmental Biology
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