Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth
Copyright policy )Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth
Significance Stem cells and the ovarian steroids estrogen and progesterone are essential for leiomyoma tissue growth. The underlying mechanisms are unknown, particularly because leiomyoma stem cells are deficient in estrogen and progesterone receptors. Expression of these receptors is much higher in surrounding mature myometrial or leiomyoma smooth muscle cells. Here, we demonstrate that wingless-type (WNT) acts as a paracrine signal from estrogen/progesterone receptor-rich mature cells to activate the canonical β-catenin pathway in leiomyoma stem cells. Our findings suggest a paracrine role for the canonical WNT pathway in the growth of leiomyoma tumor.
- Northwestern University United States
- Keio University Japan
- Northwestern University Philippines
Adult, Leiomyoma, Estrogens, Mice, SCID, Middle Aged, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Mice, Axin Protein, Mice, Inbred NOD, Pregnancy, Paracrine Communication, Uterine Neoplasms, Neoplastic Stem Cells, Animals, Humans, Female, Transcription Factor 7-Like 2 Protein, Progesterone, Cell Proliferation
Adult, Leiomyoma, Estrogens, Mice, SCID, Middle Aged, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Mice, Axin Protein, Mice, Inbred NOD, Pregnancy, Paracrine Communication, Uterine Neoplasms, Neoplastic Stem Cells, Animals, Humans, Female, Transcription Factor 7-Like 2 Protein, Progesterone, Cell Proliferation
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