Serum and Synovial Fluid Nesfatin-1 Concentration is Associated with Radiographic Severity of Knee Osteoarthritis
Copyright policy )Serum and Synovial Fluid Nesfatin-1 Concentration is Associated with Radiographic Severity of Knee Osteoarthritis
Nesfatin-1, a member of the adipokine family, has been detected in synovial fluid (SF) from OA patients. This study aimed to determine whether there is a marked correlation of nesfatin-1 levels in serum and SF of knee OA patients with the disease severity of OA.This cross-sectional research enrolled 202 knee OA subjects. The Kellgren-Lawrence grading system was utilized to evaluate the severity of knee OA.Elevated nesfatin-1 concentrations in serum were found in knee OA patients compared with the controls. Nesfatin-1 concentrations were markedly elevated with increased KL grades. Serum and SF nesfatin-1 concentrations were both significantly associated with the disease severity evaluated by KL grading criteria.Our investigation indicates a marked association of serum and SF nesfatin-1 concentrations with OA disease severity.
- Southern Medical University China (People's Republic of)
- Third Affiliated Hospital of Southern Medical University China (People's Republic of)
- Nanfang Hospital China (People's Republic of)
- Second Affiliated Hospital of Guangzhou Medical University China (People's Republic of)
- Wenzhou Medical University China (People's Republic of)
Male, Calcium-Binding Proteins, Nerve Tissue Proteins, Middle Aged, Osteoarthritis, Knee, Severity of Illness Index, DNA-Binding Proteins, Radiography, Clinical Research, Case-Control Studies, Synovial Fluid, Humans, Nucleobindins, Female
Male, Calcium-Binding Proteins, Nerve Tissue Proteins, Middle Aged, Osteoarthritis, Knee, Severity of Illness Index, DNA-Binding Proteins, Radiography, Clinical Research, Case-Control Studies, Synovial Fluid, Humans, Nucleobindins, Female
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