Classifying Cancers Based on T-cell Infiltration and PD-L1
Copyright policy )Classifying Cancers Based on T-cell Infiltration and PD-L1
Abstract Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus, the tumor has many strategies to evade an immune response. It has been proposed that four different types of tumor microenvironment exist based on the presence or absence of tumor-infiltrating lymphocytes and programmed death-ligand 1 (PD-L1) expression. We review this stratification and the latest in a series of results that shed light on new approaches for rationally designing ideal combination cancer therapies based on tumor immunology. Cancer Res; 75(11); 2139–45. ©2015 AACR.
- University of California, Los Angeles United States
- University of California, San Francisco United States
- UCLA Health United States
- UCLA Jonsson Comprehensive Cancer Center United States
- University of Queensland Australia
Oncology and Carcinogenesis, Expression, CD8-Positive T-Lymphocytes, Immune Contexture, B7-H1 Antigen, Vaccine Related, Lymphocytes, Tumor-Infiltrating, Neoplasms, Tumor Microenvironment, Responses, Humans, 1306 Cancer Research, Oncology & Carcinogenesis, Lymphocytes, Tumor-Infiltrating, Pathways, Lung, Cancer, Neoplastic, Anti-Pd-L1 Antibody, Lung Cancer, Antitumor, Blockade, Gene Expression Regulation, Neoplastic, Nivolumab, Gene Expression Regulation, 2730 Oncology, Immunization, Immunotherapy, Safety
Oncology and Carcinogenesis, Expression, CD8-Positive T-Lymphocytes, Immune Contexture, B7-H1 Antigen, Vaccine Related, Lymphocytes, Tumor-Infiltrating, Neoplasms, Tumor Microenvironment, Responses, Humans, 1306 Cancer Research, Oncology & Carcinogenesis, Lymphocytes, Tumor-Infiltrating, Pathways, Lung, Cancer, Neoplastic, Anti-Pd-L1 Antibody, Lung Cancer, Antitumor, Blockade, Gene Expression Regulation, Neoplastic, Nivolumab, Gene Expression Regulation, 2730 Oncology, Immunization, Immunotherapy, Safety
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