Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice.
Copyright policy )Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice.
Mice with a homozygous deletion in their Tap-1 gene (-/- mice) express very low levels of cell membrane major histocompatibility complex class I molecules and have < 1% peripheral CD8+ T cells. We show that these -/- mice but not their +/- littermates display strong primary syngeneic anti-H-2Kb and -Db-specific responses mediated by CD8+ T cells. These responses are augmented by in vivo priming. Further, -/- mice primed in vivo with H-2d alloantigens generate an anti-H-2d response which appears nearly as strong as that found in +/- littermates. Both -/- anti-H-2b and anti-H-2d T cells do not recognize target cells from Tap-1 -/- animals or Tap-2-deficient RMA-S cells. Thus, some CD8+ anti-self and alloreactive T cells can be selected in the absence of Tap proteins.
- Massachusetts Institute of Technology United States
- Howard Hughes Medical Institute United States
- Vanderbilt University United States
- The University of Texas Southwestern Medical Center United States
- Karolinska Institute Sweden
Cytotoxicity, Immunologic, T-Lymphocytes, H-2 Antigens, Lymphocyte Activation, Mice, Mutant Strains, Mice, Inbred C57BL, Mice, Animals, ATP-Binding Cassette Transporters, ATP Binding Cassette Transporter, Subfamily B, Member 2, Carrier Proteins, beta 2-Microglobulin, Neoplasm Transplantation, Spleen, T-Lymphocytes, Cytotoxic
Cytotoxicity, Immunologic, T-Lymphocytes, H-2 Antigens, Lymphocyte Activation, Mice, Mutant Strains, Mice, Inbred C57BL, Mice, Animals, ATP-Binding Cassette Transporters, ATP Binding Cassette Transporter, Subfamily B, Member 2, Carrier Proteins, beta 2-Microglobulin, Neoplasm Transplantation, Spleen, T-Lymphocytes, Cytotoxic
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