Nogo CAA 3′UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder
Copyright policy )Nogo CAA 3′UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder
The Nogo gene maps to 2p14-p13, a region consistently associated with schizophrenia and bipolar disorder. The association of a polymorphism in Nogo was previously investigated by two groups, with divergent results. In this report, using an alternative approach, we evaluated this same polymorphism in 725 individuals, including patients with schizophrenia, bipolar disorder, normal controls and non-human primate samples. Our results indicate that the polymorphism is not associated with any of these diseases, but has a remarkably biased distribution in ethnic groups. Genotyping of primate samples, suggest that this polymorphism is a recent event in human speciation.
- Universidade de São Paulo Brazil
- UNIVERSIDADE DE SAO PAULO Brazil
- Universidade Federal de Minas Gerais Brazil
Adult, Male, Bipolar Disorder, Polymorphism, Genetic, Nogo Proteins, Racial Groups, Haplorhini, Mutagenesis, Insertional, Untranslated Regions, Case-Control Studies, DNA Transposable Elements, Schizophrenia, Animals, Humans, Female, Genetic Predisposition to Disease, Brazil, Myelin Proteins
Adult, Male, Bipolar Disorder, Polymorphism, Genetic, Nogo Proteins, Racial Groups, Haplorhini, Mutagenesis, Insertional, Untranslated Regions, Case-Control Studies, DNA Transposable Elements, Schizophrenia, Animals, Humans, Female, Genetic Predisposition to Disease, Brazil, Myelin Proteins
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