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Ets-1 upregulates HER2-induced MMP-1 expression in breast cancer cells

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2008Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 377, pages 389-394 (issn: 0006-291X,

Authors: Jin Seok Ahn; Young-Hyuck Im; Hae Hyun Jung; Yeon Hee Park;

doi: 10.1016/j.bbrc.2008.09.135

pmid: 18851945

Ets-1 upregulates HER2-induced MMP-1 expression in breast cancer cells

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Abstract

The human epidermal growth factor receptor-2 (HER2) plays an important role in breast cancer. Enhanced Ets-1 activity has recently been shown to be associated with breast cancer pathogenesis. To test the role of Ets-1 in breast cancer cells in relation to the expression of HER2 and MMP-1, we transiently overexpressed Ets-1 and/or HER2 in MCF-7 breast cancer cells and comprehensively searched for genes related to HER2 and Ets-1 using cDNA microarray analysis. The expression of matrix metalloproteinase (MMP) genes was enhanced by the overexpression of HER2/Ets-1. We analyzed the relationship between HER2-induced MMP-1 expression and the transcription factor Ets-1, which has significant activity in breast cancer pathogenesis. Our results demonstrate that HER2-induced MMP-1 expression is positively regulated by Ets-1 in breast cancer cells. This study confirms that Ets-1 is a downstream effector of oncogenic HER2, associated with MMP-1.

Related Organizations

Samsung Medical Center
Korea (Republic of)
Sungkyunkwan University
Korea (Republic of)
Biomedical Research Institute
United States

Keywords

Receptor, ErbB-2, Down-Regulation, Breast Neoplasms, Transfection, ErbB Receptors, Proto-Oncogene Protein c-ets-1, Cell Line, Tumor, Humans, Matrix Metalloproteinase 1, Phosphorylation, Promoter Regions, Genetic, Oligonucleotide Array Sequence Analysis

30 Research products, page 1 of 3

Matrix metalloproteinase 1
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ZnMc domain-containing protein
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cDNA FLJ55711, highly similar to Receptor tyrosine-protein kinase erbB-2
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ETS1 protein
2017IsRelatedTo
Protein C-ets-1
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Herstatin
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Matrix metalloproteinase 1 (Interstitial collagenase)
2017IsRelatedTo
Receptor protein-tyrosine kinase
2017IsRelatedTo
Matrix metalloproteinase 1 preproprotein variant
2017IsRelatedTo
Interstitial collagenase
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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	41
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