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Essential Role of the Glycosyltransferase Sxc/Ogt in Polycomb Repression

descriptionPublicationkeyboard_double_arrow_right Article 03 Jul 2009 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 325, pages 93-96 (issn: 0036-8075, eissn: 1095-9203,

Authors: Jürg Müller; Katarzyna Oktaba; Maria Cristina Gambetta;

doi: 10.1126/science.1169727

pmid: 19478141

Essential Role of the Glycosyltransferase Sxc/Ogt in Polycomb Repression

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Abstract

Putting the Sugar on Polycomb A wide variety of nuclear and cytosolic proteins in human cells carry an O-linked sugar modification, N -acetylglucosamine (GlcNAc), which is added by the highly conserved O-linked GlcNAc transferase, Ogt. Gambetta et al. (p. 93 , published online 28 May; see the Perspective by Simon ) show that in Drosophila , Ogt is encoded by super sex combs, a classic Polycomb group gene known for its role in repressing developmental regulator genes. GlcNAc modification is highly enriched at chromosomal sites bound by Polycomb group proteins, and one of these, Polyhomeotic, is modified by Ogt. Thus, in Drosophila , it seems that O-linked GlcNAc has a very specific role to effect Polycomb repression.

Related Organizations

European Bioinformatics Institute
United Kingdom
European Molecular Biology Laboratory
Germany

Keywords

Polycomb Repressive Complex 1, Chromatin Immunoprecipitation, Glycosylation, Transcription, Genetic, Polycomb-Group Proteins, Genes, Insect, Chromatin, Acetylglucosamine, DNA-Binding Proteins, Repressor Proteins, Protein Subunits, Drosophila melanogaster, Nucleoproteins, Animals, Drosophila Proteins, Gene Silencing, Protein Binding

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