Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts
Copyright policy )Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts
During neuroblast (NB) divisions, cell fate determinants Prospero (Pros) and Numb, together with their adaptor proteins Miranda (Mira) and Partner of Numb, localize to the basal cell cortex at metaphase and segregate exclusively to the future ganglion mother cells (GMCs) at telophase. In inscuteable mutant NBs, these basal proteins are mislocalized during metaphase. However, during anaphase/telophase, these mutant NBs can partially correct these earlier localization defects and redistribute cell fate determinants as crescents to the region where the future GMC "buds" off. This compensatory mechanism has been referred to as "telophase rescue". We demonstrate that the Drosophila homolog of the mammalian tumor-necrosis factor (TNF) receptor-associated factor (DTRAF1) and Eiger (Egr), the homolog of the mammalian TNF, are required for telophase rescue of Mira/Pros. DTRAF1 localizes as an apical crescent in metaphase NBs and this apical localization requires Bazooka (Baz) and Egr. The Mira/Pros telophase rescue seen in inscuteable mutant NBs requires DTRAF1. Our data suggest that DTRAF1 binds to Baz and acts downstream of Egr in the Mira/Pros telophase rescue pathway.
- National University of Singapore Singapore
- Institute of Molecular and Cell Biology Singapore
- National University of Singapore Libraries Singapore
- Agency for Science, Technology and Research Singapore
- Biomedical Research Council Singapore
570, Baz function, Embryo, Nonmammalian, Cell Cycle Proteins, Nerve Tissue Proteins, Neuroblast asymmetric division, DTRAF1, Chromosome Segregation, Animals, Drosophila Proteins, Cell Lineage, Metaphase, Mammals, Neurons, Egr, Intracellular Signaling Peptides and Proteins, Cell Polarity, Membrane Proteins, Nuclear Proteins, Juvenile Hormones, Cytoskeletal Proteins, Protein Transport, Telophase rescue, Mutation, Drosophila, Carrier Proteins
570, Baz function, Embryo, Nonmammalian, Cell Cycle Proteins, Nerve Tissue Proteins, Neuroblast asymmetric division, DTRAF1, Chromosome Segregation, Animals, Drosophila Proteins, Cell Lineage, Metaphase, Mammals, Neurons, Egr, Intracellular Signaling Peptides and Proteins, Cell Polarity, Membrane Proteins, Nuclear Proteins, Juvenile Hormones, Cytoskeletal Proteins, Protein Transport, Telophase rescue, Mutation, Drosophila, Carrier Proteins
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