Genetic mapping of the mouse X chromosome in the region homologous to human Xq27–Xq28
Copyright policy )Genetic mapping of the mouse X chromosome in the region homologous to human Xq27–Xq28
The four loci Gabra3, DXPas8, CamL1, and Bpa, located near the murine X-linked visual pigment gene (Rsvp), have been ordered using 248 backcross progeny from an interspecific mating of (B6CBA-Aw-J/A-Bpa) and Mus spretus. One hundred twenty backcross progeny have been analyzed at seven anchor loci spanning the X chromosome and form a regional mapping panel. An additional 128 progeny have been screened for recombination events between Cf-9 and Dmd. Eighteen recombinants between these loci have been detected in the 248 animals; all of the recombinants were screened at the other anchor loci to identify any double crossovers. Pedigree analysis using these recombinants strongly favors a gene order of (Cf-9)-Gabra3-(DXPas8, Bpa)-CamL1-(Rsvp, P3, Cf-8)-Dmd for the loci studied. Synteny with human Xq27-Xq28 is retained, although the relative order of some loci may differ between the two species.
- MRC Laboratory of Molecular Biology United Kingdom
- Baylor College of Medicine United States
- Medical Research Council United Kingdom
Male, Recombination, Genetic, X Chromosome, Genetic Linkage, Chromosome Mapping, Mice, Inbred C57BL, Mice, Sequence Homology, Nucleic Acid, Mice, Inbred CBA, Animals, Humans, Female, Crosses, Genetic, Polymorphism, Restriction Fragment Length
Male, Recombination, Genetic, X Chromosome, Genetic Linkage, Chromosome Mapping, Mice, Inbred C57BL, Mice, Sequence Homology, Nucleic Acid, Mice, Inbred CBA, Animals, Humans, Female, Crosses, Genetic, Polymorphism, Restriction Fragment Length
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