Identification of a polymorphic, neuron-specific chromatin remodeling complex
Copyright policy )Identification of a polymorphic, neuron-specific chromatin remodeling complex
A variety of chromatin remodeling complexes are thought to assist sequence-specific transcription factors. The complexes described to date are expressed ubiquitously, suggesting that they have general transcriptional functions. We show that vertebrate neurons have a specialized chromatin remodeling complex, bBAF, specifically containing the actin-related protein, BAF53b, which is first expressed in postmitotic neurons at about murine embryonic day 12.5 (E12.5). BAF53b is combinatorially assembled into polymorphic complexes with ubiquitous subunits including the two ATPases BRG1 and BRM. We speculate that bBAF complexes create neuronal-specific patterns of chromatin accessibility, thereby imparting new regulatory characteristics to ubiquitous sequence-specific transcription factors in neurons.
- Stanford University United States
- Howard Hughes Medical Institute United States
- National Institutes of Health United States
Neurons, Polymorphism, Genetic, Sequence Homology, Amino Acid, Chromosomal Proteins, Non-Histone, Molecular Sequence Data, DNA Helicases, Brain, Gene Expression, Nuclear Proteins, Actins, Chromatin, DNA-Binding Proteins, Mice, Animals, Humans, Amino Acid Sequence, HeLa Cells, Transcription Factors
Neurons, Polymorphism, Genetic, Sequence Homology, Amino Acid, Chromosomal Proteins, Non-Histone, Molecular Sequence Data, DNA Helicases, Brain, Gene Expression, Nuclear Proteins, Actins, Chromatin, DNA-Binding Proteins, Mice, Animals, Humans, Amino Acid Sequence, HeLa Cells, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).142 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!