Paired Related Homeobox Protein 1 is a Regulator of Stemness in Adult Neural Stem/Progenitor Cells
Copyright policy )Paired Related Homeobox Protein 1 is a Regulator of Stemness in Adult Neural Stem/Progenitor Cells
Newborn neurons are generated from neural stem cells (NSCs) in two major niches of the adult brain. Maintenance of self-renewal and multipotency of adult NSCs is controlled by multiple transcription factor networks. We show here that paired related homeobox protein Prx1 (MHox1/Prrx1) plays an important role in the maintenance of adult NSCs. Prx1 works with the transcription factor Sox2 as a coactivator, and depletion of Prx1 in cultured adult mouse NSCs reduces their self-renewal. In addition, we find that Prx1 protein is expressed in Sox2+/GFAP+/Nestin+astrocytes in the germinal regions of the adult mouse forebrain. The continuous expression of Prx1 in proliferating adult mouse hippocampal stem/progenitor cellsin vivoleads to the generation of radial/horizontal-shaped astrocyte progenitor- and oligodendrocyte progenitor-like cells with no newborn neurons in the neurogenic niche. These data suggest that Prx1 plays an important role as a key switch for neural cell lineage determination and the maintenance of the self-renewal of adult NSCs at several stages in the adult brain.
- Nagasaki University Japan
- Nagasaki University Japan
- Salk Institute for Biological Studies United States
Homeodomain Proteins, Neurons, Caspase 3, Gene Expression Profiling, Green Fluorescent Proteins, Cell Differentiation, Mice, Transgenic, Nerve Tissue Proteins, Mice, Inbred C57BL, Adult Stem Cells, Mice, Bromodeoxyuridine, Gene Expression Regulation, Astrocytes, Animals, Humans, Female, Cells, Cultured, Cell Proliferation, Oligonucleotide Array Sequence Analysis
Homeodomain Proteins, Neurons, Caspase 3, Gene Expression Profiling, Green Fluorescent Proteins, Cell Differentiation, Mice, Transgenic, Nerve Tissue Proteins, Mice, Inbred C57BL, Adult Stem Cells, Mice, Bromodeoxyuridine, Gene Expression Regulation, Astrocytes, Animals, Humans, Female, Cells, Cultured, Cell Proliferation, Oligonucleotide Array Sequence Analysis
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