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VEGFR2 is selectively expressed by FOXP3high CD4+ Treg

descriptionPublicationkeyboard_double_arrow_right Article 30 Dec 2009Publisher:WileyJournal:European Journal of Immunology, volume 40, pages 197-203 (issn: 0014-2980, eissn: 1521-4141,

Authors: Hideya Onishi; Mitsuo Katano; Haruo Tanaka; Kenji Nakano; Hiroyuki Suzuki; Junji Wada; Akio Yamasaki; +1 Authors

doi: 10.1002/eji.200939887

pmid: 19902430

VEGFR2 is selectively expressed by FOXP3high CD4+ Treg

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Abstract

AbstractCD25+ FOXP3+CD4+ T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high‐level expression of FOXP3 (FOXP3high) is sufficient to confer suppressive activity to normal non‐Treg. Here, we showed for the first time that vascular endothelial growth factor receptor 2 (VEGFR2) is selectively expressed by FOXP3high but not FOXP3low Treg. Such VEGFR2+ Treg exist in several tissues including PBMC and malignant effusion‐derived lymphocytes. In conclusion, VEGFR2 may be a novel target for controlling Treg with highly suppressive function.

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Kyushu University
Japan

Keywords

Transforming Growth Factor beta, Neoplasms, Humans, Forkhead Transcription Factors, Immunotherapy, T-Lymphocytes, Regulatory, Vascular Endothelial Growth Factor Receptor-2

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27 Research products, page 1 of 3

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	114
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