Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice
Copyright policy )Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice
Using nociceptin-receptor-deficient mice, we studied the participation of nociceptin in herpetic and postherpetic allodynia in mice. Although nociceptin-receptor deficiency did not affect the development of skin lesions and herpetic allodynia, it prevented postherpetic allodynia. Messenger ribonucleic acid (mRNA) of pronociceptin increased in the dorsal horn of lumbar enlargement on day 6, but not on day 40, after inoculation. No changes were observed in the mRNA of the nociceptin receptor. Inhibition of herpetic allodynia by repeated oral administration of gabapentin (100 mg/kg) alleviated the overexpression of mRNA of pronociceptin, as well as the severity of postherpetic allodynia. These results suggest that the spinal nociceptin system is involved in the transitional process from herpetic allodynia to postherpetic allodynia.
- University of Toyama Japan
- Kyoto University Japan
- Tohoku Medical and Pharmaceutical University Japan
Mice, Knockout, Analgesics, Time Factors, Cyclohexanecarboxylic Acids, Herpes Simplex, Herpesvirus 1, Human, Mice, Inbred C57BL, Disease Models, Animal, Mice, Gene Expression Regulation, Spinal Cord, Hyperalgesia, Acute Disease, Receptors, Opioid, Animals, RNA, Messenger, Amines, Gabapentin, Protein Precursors, Pain Measurement
Mice, Knockout, Analgesics, Time Factors, Cyclohexanecarboxylic Acids, Herpes Simplex, Herpesvirus 1, Human, Mice, Inbred C57BL, Disease Models, Animal, Mice, Gene Expression Regulation, Spinal Cord, Hyperalgesia, Acute Disease, Receptors, Opioid, Animals, RNA, Messenger, Amines, Gabapentin, Protein Precursors, Pain Measurement
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