An Antibody That Prevents the Hemagglutinin Low pH Fusogenic Transition
Copyright policy )An Antibody That Prevents the Hemagglutinin Low pH Fusogenic Transition
We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition.
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Models, Molecular, [SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Protein Conformation, membrane fusion, Antibody Affinity, Hemagglutinin Glycoproteins, Influenza Virus, Hydrogen-Ion Concentration, Antibodies, Viral, Orthomyxoviridae, Membrane Fusion, Immunoglobulin Fab Fragments, antibody, Virology, hemagglutinin, structure, influenza
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Models, Molecular, [SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Protein Conformation, membrane fusion, Antibody Affinity, Hemagglutinin Glycoproteins, Influenza Virus, Hydrogen-Ion Concentration, Antibodies, Viral, Orthomyxoviridae, Membrane Fusion, Immunoglobulin Fab Fragments, antibody, Virology, hemagglutinin, structure, influenza
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