Exonuclease 1-dependent and independent mismatch repair
Copyright policy )Exonuclease 1-dependent and independent mismatch repair
DNA mismatch repair (MMR) acts to repair mispaired bases resulting from misincorporation errors during DNA replication and also recognizes mispaired bases in recombination (HR) intermediates. Exonuclease 1 (Exo1) is a 5' → 3' exonuclease that participates in a number of DNA repair pathways. Exo1 was identified as an exonuclease that participates in Saccharomyces cerevisiae and human MMR where it functions to excise the daughter strand after mispair recognition, and additionally Exo1 functions in end resection during HR. However, Exo1 is not absolutely required for end resection during HR in vivo. Similarly, while Exo1 is required in MMR reactions that have been reconstituted in vitro, genetics studies have shown that it is not absolutely required for MMR in vivo suggesting the existence of Exo1-independent and Exo1-dependent MMR subpathways. Here, we review what is known about the Exo1-independent and Exo1-dependent subpathways, including studies of mutations in MMR genes that specifically disrupt either subpathway.
- Moores Cancer Center United States
- Ludwig Cancer Research Belgium
- University of California, San Diego United States
- University of California, San Diego United States
- University of California, San Francisco United States
DNA Replication, Models, Molecular, Protein Structure, Secondary, Base Pair Mismatch, Msh2–Msh6, DNA replication fidelity, Saccharomyces cerevisiae, Excision, DNA Mismatch Repair, Protein Structure, Secondary, Double-Stranded, Mlh1–Pms1, Models, Gene Expression Regulation, Fungal, Genetics, Humans, DNA Breaks, Double-Stranded, DNA, Fungal, Msh2-Msh6, DNA Breaks, Molecular, DNA, Biological Sciences, Recombination, Protein Structure, Tertiary, Fungal, Exodeoxyribonucleases, Gene Expression Regulation, Mutagenesis, Biochemistry and cell biology, Mutation, Biochemistry and Cell Biology, Mlh1-Pms1, Mispaired base, Tertiary, Developmental Biology
DNA Replication, Models, Molecular, Protein Structure, Secondary, Base Pair Mismatch, Msh2–Msh6, DNA replication fidelity, Saccharomyces cerevisiae, Excision, DNA Mismatch Repair, Protein Structure, Secondary, Double-Stranded, Mlh1–Pms1, Models, Gene Expression Regulation, Fungal, Genetics, Humans, DNA Breaks, Double-Stranded, DNA, Fungal, Msh2-Msh6, DNA Breaks, Molecular, DNA, Biological Sciences, Recombination, Protein Structure, Tertiary, Fungal, Exodeoxyribonucleases, Gene Expression Regulation, Mutagenesis, Biochemistry and cell biology, Mutation, Biochemistry and Cell Biology, Mlh1-Pms1, Mispaired base, Tertiary, Developmental Biology
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