Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice
Copyright policy )Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice
To investigate the role of retinal-based pigments (opsins) in circadian photoreception in mice, animals mutated in plasma retinol binding protein were placed on a vitamin A-free diet and tested for photic induction of gene expression in the suprachiasmatic nucleus. After 10 months on the vitamin A-free diet, the majority of mice contained no detectable retinal in their eyes. These mice demonstrated fully intact photic signaling to the suprachiasmatic nucleus as measured by acute mPer mRNA induction in the suprachiasmatic nucleus in response to bright or dim light. The data suggest that a non-opsin pigment is the primary circadian photoreceptor in the mouse.
- Columbia University United States
- University of North Carolina at Chapel Hill United States
- University of Sannio Italy
- University Physicians United States
- Washington University in St. Louis United States
Male, Time Factors, Vitamin A Deficiency, Homozygote, Circadian Rhythm, Mice, Inbred C57BL, Retinol-Binding Proteins, Mice, Reference Values, Retinaldehyde, Animals, Female, Suprachiasmatic Nucleus, Retinol-Binding Proteins, Plasma, Crosses, Genetic, In Situ Hybridization, Photoreceptor Cells, Vertebrate, Signal Transduction
Male, Time Factors, Vitamin A Deficiency, Homozygote, Circadian Rhythm, Mice, Inbred C57BL, Retinol-Binding Proteins, Mice, Reference Values, Retinaldehyde, Animals, Female, Suprachiasmatic Nucleus, Retinol-Binding Proteins, Plasma, Crosses, Genetic, In Situ Hybridization, Photoreceptor Cells, Vertebrate, Signal Transduction
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