Novel DNA polymorphism in the mouse tumor necrosis factor receptors type 1 and type 2
Copyright policy )Novel DNA polymorphism in the mouse tumor necrosis factor receptors type 1 and type 2
The introduction of the polymerase chain reaction (PCR) provides an entirely new means of analyzing DNA polymorphism and makes practical the analysis of length variation in simple-sequence tandem repeats of dinucleotides. In the process of cloning and sequencing the mouse genomic DNA for tumor necrosis factor (TNF) receptors type 1 and type 2, we identified two simple dinucleotide repeats within the noncoding regions of TNF receptor type 1 and three such sequences within TNF receptor type 2. PCR analysis of these sequences, using genomic DNA from 21 different inbred and wild mouse strains, as demonstrated by running the amplified products on sequencing gels, showed that the repeats are highly polymorphic. We identified seven alleles of TNF receptor type 2 and five alleles of TNF receptor type 1. Using these polymorphic markers in two sets of recombinant inbred strains of mice, the chromosomal localization of Tnfr-1 was mapped to mouse chromosome 6 and Tnfr-2 was located to the distal portion of mouse chromosome 4.
Polymorphism, Genetic, Base Sequence, Molecular Sequence Data, Chromosome Mapping, Mice, Inbred Strains, Receptors, Cell Surface, DNA, Receptors, Tumor Necrosis Factor, Muridae, Mice, Animals
Polymorphism, Genetic, Base Sequence, Molecular Sequence Data, Chromosome Mapping, Mice, Inbred Strains, Receptors, Cell Surface, DNA, Receptors, Tumor Necrosis Factor, Muridae, Mice, Animals
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).14 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!