Putative association betweenUBE2E2polymorphisms and the risk of gestational diabetes mellitus
Copyright policy )Putative association betweenUBE2E2polymorphisms and the risk of gestational diabetes mellitus
We hypothesized that ubiquitin-conjugating enzyme E2 E2 (UBE2E2) may be associated with gestational diabetes mellitus (GDM) and conducted association analyses. A total of 2071 subjects were recruited for the study, with 1104 cases and 967 controls. Two UBE2E2 single-nucleotide polymorphisms rs6780569 and rs7612463, and their haplotypes were analyzed for the study. As a result, rs7612463 showed a significant association with GDM in the recessive model. In addition, the regression analyses for the phenotypes showed that rs6780569. rs7612463 and ht2 showed significant associations with fasting plasma glucose (FPG) in recessive models, while ht1 showed an association in the dominant model. Our results show that the genetic variants of UBE2E2 are associated with GDM and FPG, which could be an important preliminary result for future studies.
- Korea University Korea (Republic of)
- Hoseo University Korea (Republic of)
- University of Seoul Korea (Republic of)
- Sogang University Korea (Republic of)
- Cheil General Hospital and Women's Healthcare Center Korea (Republic of)
Adult, Blood Glucose, Risk, Fasting, Middle Aged, Polymorphism, Single Nucleotide, Diabetes, Gestational, Young Adult, Haplotypes, Pregnancy, Case-Control Studies, Ubiquitin-Conjugating Enzymes, Humans, Female, Genetic Predisposition to Disease, Genetic Association Studies
Adult, Blood Glucose, Risk, Fasting, Middle Aged, Polymorphism, Single Nucleotide, Diabetes, Gestational, Young Adult, Haplotypes, Pregnancy, Case-Control Studies, Ubiquitin-Conjugating Enzymes, Humans, Female, Genetic Predisposition to Disease, Genetic Association Studies
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