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CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2003 English Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 308, pages 170-176 (issn: 0006-291X,

Authors: James R. Davie; Margit Geisterfer; John C. Bell; Michael W. McBurney; Lorrie Boucher; Helen H. Tai; Mariko Moniwa;

doi: 10.1016/s0006-291x(03)01354-8

pmid: 12890497

CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins

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Abstract

CHD1 is one of a family of nuclear proteins containing two chromodomains, a SWI/SNF-like helicase/ATPase domain and a DNA binding domain. We found that CHD1 co-immunoprecipitates with histone deacetylase (HDAC) activity and that CHD1 also associates with NCoR, a transcriptional corepressor, in yeast two-hybrid and in vitro pull-down assays. NCoR is known to associate with HDACs to effect its repressive activity, suggesting that the predicted chromatin remodeling activity of CHD1 plays a role in this repression. Yeast two-hybrid assays also showed that CHD1 interacts with splicing proteins mKIAA0164, Srp20, and SAF-B. Splicing assays show that CHD1 overexpression can affect alternative splicing. These results suggest that CHD1 may function in both chromatin mediated transcriptional repression and RNA splicing.

Related Organizations

University of Ottawa
Canada
University of Ottawa
Canada

Keywords

Base Sequence, RNA Splicing, DNA Helicases, Nuclear Proteins, Histone Deacetylases, Cell Line, DNA-Binding Proteins, Repressor Proteins, Humans, Nuclear Receptor Co-Repressor 1, DNA Primers, Protein Binding

22 Research products, page 1 of 3

Nuclear receptor co-repressor 1, isoform CRA_a
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NCOR1 protein
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Chromodomain-helicase-DNA-binding protein 1
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NCOR1 protein
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NCOR isoform d
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NCOR1 protein
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Nuclear receptor co-repressor isoform 2
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NCOR isoform c
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cDNA FLJ50924, highly similar to Nuclear receptor corepressor 1
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Nuclear receptor corepressor 1
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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	51
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