Lack of replication of association between GIGYF2 variants and Parkinson disease
Copyright policy )Lack of replication of association between GIGYF2 variants and Parkinson disease
Mutations in GIGYF2 have recently been described as causative of Parkinson's disease in Europeans. In an attempt to replicate these results in independent populations, we sequenced the entire coding region of GIGYF2 in a large series of Portuguese and North American samples. We report the finding of two of the previously published mutations in neurologically normal Control individuals. This suggests that mutations in GIGYF2 are not strongly related to the development of the disease in either of these populations.
- National Institute of Health Pakistan
- University of Coimbra Portugal
- Biomedical Institute of Valencia Spain
- Hospitais da Universidade de Coimbra Portugal
- University of Virginia United States
Male, Portugal, Reproducibility of Results, Parkinson Disease, Middle Aged, Polymorphism, Single Nucleotide, United States, Cohort Studies, Case-Control Studies, Mutation, Humans, Female, Carrier Proteins, Aged
Male, Portugal, Reproducibility of Results, Parkinson Disease, Middle Aged, Polymorphism, Single Nucleotide, United States, Cohort Studies, Case-Control Studies, Mutation, Humans, Female, Carrier Proteins, Aged
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