Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell Carcinoma
Copyright policy )Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell Carcinoma
The neurokinin 3 receptor (NK-3R) is differentially expressed in the central nervous system including cases of human oral squamous cell carcinoma. However, the role of NK-3R signaling in oral squamous cell carcinoma is not well known.NK-3R expression in surgically resected oral squamous cell carcinoma was examined immunohistochemically and the strength of the expression was quantified. We evaluated the function of NK-3R signaling using NK-3R antagonist in human oral squamous cell carcinoma bone invasion mouse model.NK-3R was significantly expressed in tumor cells that had invaded the bone matrix compared to the oral side tumor cells. SB222200, a selective antagonist of NK-3R, significantly suppressed the radiographic osteolytic lesion and tumorigenesis.NK-3R signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction.
- Okayama University Japan
Male, Mice, Inbred BALB C, Mice, Nude, Apoptosis, Receptors, Neurokinin-3, Prognosis, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Mice, Cell Movement, Carcinoma, Squamous Cell, Quinolines, Tumor Cells, Cultured, Animals, Humans, Mouth Neoplasms, Bone Resorption, Cell Proliferation, Retrospective Studies
Male, Mice, Inbred BALB C, Mice, Nude, Apoptosis, Receptors, Neurokinin-3, Prognosis, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Mice, Cell Movement, Carcinoma, Squamous Cell, Quinolines, Tumor Cells, Cultured, Animals, Humans, Mouth Neoplasms, Bone Resorption, Cell Proliferation, Retrospective Studies
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