Associations between polymorphisms in theNR1D1gene encoding for nuclear receptor REV-ERBαand circadian typologies
Copyright policy )Associations between polymorphisms in theNR1D1gene encoding for nuclear receptor REV-ERBαand circadian typologies
Nuclear receptor REV-ERBα, a key component of an internal timekeeping system, has been considered to be related to disrupted circadian rhythms and mood disorder. In this study, we aimed to evaluate the relationship between the genotype frequencies of single gene polymorphisms (SNPs) of the NR1D1 gene encoding REV-ERBα and circadian typologies. The classification of chronotypes and genotyping of three SNPs (rs2314339, rs2071427, rs12941497) of the NR1D1 gene were conducted in 602 healthy young adults (355 males, 247 females). A significant association was found between the genotypes of rs12941497 and three chronotype categories. These findings support the role of NR1D1 polymorphisms in the regulation of circadian rhythms.
- Yonsei University Health System Korea (Republic of)
- Yonsei University Medical Library Korea (Republic of)
- Yonsei University Korea (Republic of)
circadian rhythm, Adult, Male, Nuclear Receptor Subfamily 1, Adolescent, Genotype, Mood Disorders/genetics*, 610, Polymorphism, Single Nucleotide, Association, Young Adult, Group D, REV-ERBα, rev/genetics*, Gene Products, Humans, genetics, Polymorphism, Genotype*, Single Nucleotide/genetics*, Mood Disorders, 600, Circadian Rhythm/genetics*, Circadian Rhythm, Member 1/genetics*, Gene Products, rev, chronotype, Nuclear Receptor Subfamily 1, Group D, Member 1, Female, NR1D1 gene
circadian rhythm, Adult, Male, Nuclear Receptor Subfamily 1, Adolescent, Genotype, Mood Disorders/genetics*, 610, Polymorphism, Single Nucleotide, Association, Young Adult, Group D, REV-ERBα, rev/genetics*, Gene Products, Humans, genetics, Polymorphism, Genotype*, Single Nucleotide/genetics*, Mood Disorders, 600, Circadian Rhythm/genetics*, Circadian Rhythm, Member 1/genetics*, Gene Products, rev, chronotype, Nuclear Receptor Subfamily 1, Group D, Member 1, Female, NR1D1 gene
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