Lack of the Sodium-Driven Chloride Bicarbonate Exchanger NCBE Impairs Visual Function in the Mouse Retina
Lack of the Sodium-Driven Chloride Bicarbonate Exchanger NCBE Impairs Visual Function in the Mouse Retina
Regulation of ion and pH homeostasis is essential for normal neuronal function. The sodium-driven chloride bicarbonate exchanger NCBE (Slc4a10), a member of the SLC4 family of bicarbonate transporters, uses the transmembrane gradient of sodium to drive cellular net uptake of bicarbonate and to extrude chloride, thereby modulating both intracellular pH (pH(i)) and chloride concentration ([Cl(-)](i)) in neurons. Here we show that NCBE is strongly expressed in the retina. As GABA(A) receptors conduct both chloride and bicarbonate, we hypothesized that NCBE may be relevant for GABAergic transmission in the retina. Importantly, we found a differential expression of NCBE in bipolar cells: whereas NCBE was expressed on ON and OFF bipolar cell axon terminals, it only localized to dendrites of OFF bipolar cells. On these compartments, NCBE colocalized with the main neuronal chloride extruder KCC2, which renders GABA hyperpolarizing. NCBE was also expressed in starburst amacrine cells, but was absent from neurons known to depolarize in response to GABA, like horizontal cells. Mice lacking NCBE showed decreased visual acuity and contrast sensitivity in behavioral experiments and smaller b-wave amplitudes and longer latencies in electroretinograms. Ganglion cells from NCBE-deficient mice also showed altered temporal response properties. In summary, our data suggest that NCBE may serve to maintain intracellular chloride and bicarbonate concentration in retinal neurons. Consequently, lack of NCBE in the retina may result in changes in pH(i) regulation and chloride-dependent inhibition, leading to altered signal transmission and impaired visual function.
- University of Tübingen Germany
- LMU Klinikum Germany
- Institut für Humangenetik Germany
- Jena University Hospital Germany
- Newcastle University United Kingdom
Retinal Bipolar Cells, Science, Visual Acuity, D300, Retinal Pigment Epithelium, Retina, Contrast Sensitivity, Mice, Electroretinography, Animals, Chloride-Bicarbonate Antiporters, Mice, Knockout, Microscopy, Confocal, Symporters, Sodium-Bicarbonate Symporters, Q, C100, R, Immunohistochemistry, C900, Amacrine Cells, K Cl- Cotransporters, Medicine, Ganglia, Photic Stimulation, Research Article
Retinal Bipolar Cells, Science, Visual Acuity, D300, Retinal Pigment Epithelium, Retina, Contrast Sensitivity, Mice, Electroretinography, Animals, Chloride-Bicarbonate Antiporters, Mice, Knockout, Microscopy, Confocal, Symporters, Sodium-Bicarbonate Symporters, Q, C100, R, Immunohistochemistry, C900, Amacrine Cells, K Cl- Cotransporters, Medicine, Ganglia, Photic Stimulation, Research Article
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