Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population
Copyright policy )Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population
We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the pro-inflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS.
- United States Department of the Interior United States
- University of KwaZulu-Natal South Africa
- Universidad de San Buenaventura, Bogota Colombia
- The University of Texas Health Science Center at San Antonio United States
- Veterans Health Administration United States
Gene dosage, Adult, Male, Unclassified drug, Receptors, CCR5, CCL3L1 chemokine, CCR5 gene, Gene Dosage, Human immunodeficiency virus 1, Major clinical study, Macrophage inflammatory protein 1alpha, Colombia, Gene, Article, Linkage Disequilibrium, Chemokine receptor CCR5, Genetic, Human immunodeficiency virus infection, Receptors, Genetic susceptibility, Haplotype, Humans, Tuberculosis, Polymorphism, Priority journal, Polymorphism, Genetic, Virus receptor, Middle Aged, CC, Logistic Models, Human cell, Haplotypes, Chemokine, DNA polymorphism, Membrane protein, Acquired immune deficiency syndrome, Case-Control Studies, Chemokines, CC, Protein expression, Genetic variability, Female, Chemokines, Controlled study, CCR5, Human
Gene dosage, Adult, Male, Unclassified drug, Receptors, CCR5, CCL3L1 chemokine, CCR5 gene, Gene Dosage, Human immunodeficiency virus 1, Major clinical study, Macrophage inflammatory protein 1alpha, Colombia, Gene, Article, Linkage Disequilibrium, Chemokine receptor CCR5, Genetic, Human immunodeficiency virus infection, Receptors, Genetic susceptibility, Haplotype, Humans, Tuberculosis, Polymorphism, Priority journal, Polymorphism, Genetic, Virus receptor, Middle Aged, CC, Logistic Models, Human cell, Haplotypes, Chemokine, DNA polymorphism, Membrane protein, Acquired immune deficiency syndrome, Case-Control Studies, Chemokines, CC, Protein expression, Genetic variability, Female, Chemokines, Controlled study, CCR5, Human
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