FIP200, a key signaling node to coordinately regulate various cellular processes
Copyright policy )FIP200, a key signaling node to coordinately regulate various cellular processes
A central question in cell biology is how various cellular processes are coordinately regulated in normal cell and how dysregulation of the normal signaling pathways leads to diseases such as cancer. Recent studies have identified FIP200 as a crucial signaling component to coordinately regulate different cellular events by its interaction with multiple signaling pathways. This review will focus on the cellular functions of FIP200 and its interacting proteins, as well as the emerging roles of FIP200 in embryogenesis and cancer development. Further understanding of FIP200 function might provide novel therapeutic targets for human diseases such as cancer.
- University of Michigan–Ann Arbor United States
- Dana-Farber Cancer Institute United States
- Harvard University United States
- University of Michigan–Flint United States
Mice, Knockout, Cell Survival, Intracellular Signaling Peptides and Proteins, Autophagy-Related Proteins, Embryonic Development, Gene Expression, Cell Differentiation, Protein-Tyrosine Kinases, Models, Biological, Mice, Cell Movement, Pregnancy, Neoplasms, Protein Biosynthesis, Animals, Humans, Female, Cell Proliferation, Signal Transduction
Mice, Knockout, Cell Survival, Intracellular Signaling Peptides and Proteins, Autophagy-Related Proteins, Embryonic Development, Gene Expression, Cell Differentiation, Protein-Tyrosine Kinases, Models, Biological, Mice, Cell Movement, Pregnancy, Neoplasms, Protein Biosynthesis, Animals, Humans, Female, Cell Proliferation, Signal Transduction
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