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Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2005 English Publisher:Elsevier BVJournal:Epilepsy Research, volume 66, pages 59-62 (issn: 0920-1211,

Authors: Marie A. Hildebrandt; Wade H. Berrettini; Russell J. Buono; Thomas N. Ferraro; Dennis J. Dlugos; Falk W. Lohoff; Michael R. Sperling; +3 Authors

doi: 10.1016/j.eplepsyres.2005.06.005

pmid: 16105728

Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy

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Abstract

Recently, an association between the C240T polymorphism in the brain-derived neurotrophic factor (BDNF) gene and partial epilepsy was demonstrated in a Japanese population. In this study we attempted to replicate the initial finding in a patient-control population of European ancestry and in addition tested whether the functional Val66Met polymorphism is associated with temporal lobe epilepsy (TLE). Genotypes of 151 TLE patients and 189 controls did not differ significantly for either of the variations. Results suggest that neither of the studied polymorphisms are strong susceptibility factors for TLE in this sample of individuals of European ancestry.

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Keywords

Adult, Male, Genotype, Brain-Derived Neurotrophic Factor, Genetic Variation, Middle Aged, Linkage Disequilibrium, Sex Factors, Epilepsy, Temporal Lobe, Gene Frequency, Humans, Female, Aged

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