The Neural Cell Adhesion Molecule NCAM2/OCAM/RNCAM, a Close Relative to NCAM
The Neural Cell Adhesion Molecule NCAM2/OCAM/RNCAM, a Close Relative to NCAM
Cell adhesion molecules (CAMs) constitute a large class of plasma membrane-anchored proteins that mediate attachment between neighboring cells and between cells and the surrounding extracellular matrix (ECM). However, CAMs are more than simple mediators of cell adhesion. The neural cell adhesion molecule (NCAM) is a well characterized, ubiquitously expressed CAM that is highly expressed in the nervous system. In addition to mediating cell adhesion, NCAM participates in a multitude of cellular events, including survival, migration, and differentiation of cells, outgrowth of neurites, and formation and plasticity of synapses. NCAM shares an overall sequence identity of ∼44% with the neural cell adhesion molecule 2 (NCAM2), a protein also known as olfactory cell adhesion molecule (OCAM) and Rb-8 neural cell adhesion molecule (RNCAM), and the region-for-region sequence homology between the two proteins suggests that they are transcribed from paralogous genes. However, very little is known about the function of NCAM2, although it originally was described more than 20 years ago. In this review, we summarize the known properties and functions of NCAM2 and describe some of the differences and similarities between NCAM and NCAM2.
- University of Copenhagen Denmark
- University of Copenhagen Denmark
Sequence Homology, Amino Acid, Molecular Sequence Data, Neural Cell Adhesion Molecule L1, Olfactory Pathways, Nervous System, Neoplasms, Animals, Humans, Protein Isoforms, Amino Acid Sequence, Autistic Disorder, Down Syndrome, Cell Adhesion Molecules, Neural Cell Adhesion Molecules, Protein Processing, Post-Translational, Sequence Alignment
Sequence Homology, Amino Acid, Molecular Sequence Data, Neural Cell Adhesion Molecule L1, Olfactory Pathways, Nervous System, Neoplasms, Animals, Humans, Protein Isoforms, Amino Acid Sequence, Autistic Disorder, Down Syndrome, Cell Adhesion Molecules, Neural Cell Adhesion Molecules, Protein Processing, Post-Translational, Sequence Alignment
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