Genetic mapping of the gene for Ca2+calmodulin-dependent protein kinase IV (Camk-4) to mouse chromosome 18
Copyright policy )Genetic mapping of the gene for Ca2+calmodulin-dependent protein kinase IV (Camk-4) to mouse chromosome 18
Southern blot analysis of Chinese hamster x mouse somatic cell hybrids was used to map the gene for a serine/threonine protein kinase expressed in brain and testis. This locus, termed Camk-4, encodes Ca2+/calmodulin-dependent protein kinase IV. Progeny of an interspecific backcross were analyzed to position Camk-4 in the centromeric region of chromosome 18 near two mutations known to affect neurological function and fertility. This raises the possibility that a defect in Camk-4 may be responsible for one of these mutant phenotypes.
- National Institutes of Health United States
- National Institute of Health Pakistan
- National Institute of Allergy and Infectious Diseases United States
- University of Colorado System United States
- University of Colorado Anschutz Medical Campus United States
Genetic Markers, Male, Chromosome Mapping, Hybrid Cells, Mice, Mutant Strains, Muridae, Mice, Mice, Neurologic Mutants, Cricetulus, Genes, Cricetinae, Infertility, Multigene Family, Calcium-Calmodulin-Dependent Protein Kinases, Animals, Protein Kinases, Calcium-Calmodulin-Dependent Protein Kinase Type 4, Crosses, Genetic, Polymorphism, Restriction Fragment Length, Protein Kinase C
Genetic Markers, Male, Chromosome Mapping, Hybrid Cells, Mice, Mutant Strains, Muridae, Mice, Mice, Neurologic Mutants, Cricetulus, Genes, Cricetinae, Infertility, Multigene Family, Calcium-Calmodulin-Dependent Protein Kinases, Animals, Protein Kinases, Calcium-Calmodulin-Dependent Protein Kinase Type 4, Crosses, Genetic, Polymorphism, Restriction Fragment Length, Protein Kinase C
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