Breast cancer risk and the BRCA1 interacting protein CTIP
Copyright policy )Breast cancer risk and the BRCA1 interacting protein CTIP
Mutations in BRCA1 predispose to breast cancer. CTIP interacts with BRCA1 and so could also be associated with increased risk. We screened CTIP for germline mutations in 210 probands of breast cancer families including 129 families with no mutations in BRCA1 or BRCA2. No coding variants were detected in CTIP, therefore, it is unlikely to be involved in breast cancer risk.
- Peter MacCallum Cancer Centre Australia
- Walter and Eliza Hall Institute of Medical Research Australia
Family Health, Male, Risk, Endodeoxyribonucleases, BRCA1 Protein, DNA Mutational Analysis, Australia, Genes, BRCA1, Nuclear Proteins, Breast Neoplasms, Mutation, Humans, Mass Screening, Female, Genetic Predisposition to Disease, Carrier Proteins, Microsatellite Repeats
Family Health, Male, Risk, Endodeoxyribonucleases, BRCA1 Protein, DNA Mutational Analysis, Australia, Genes, BRCA1, Nuclear Proteins, Breast Neoplasms, Mutation, Humans, Mass Screening, Female, Genetic Predisposition to Disease, Carrier Proteins, Microsatellite Repeats
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