Keeping stem cells under control: New insights into the mechanisms that limit niche‐stem cell signaling within the reproductive system
Copyright policy )Keeping stem cells under control: New insights into the mechanisms that limit niche‐stem cell signaling within the reproductive system
SUMMARYAdult stem cells reside in specialized microenvironments, called niches, that maintain stem cells in an undifferentiated and self‐renewing state. Defining and understanding the mechanisms that restrict niche signaling exclusively to stem cells is crucial to determine how stem cells undergo self‐renewal while their progeny, often located just one cell diameter away from the niche, differentiate. Despite extensive studies on the signaling pathways that operate within stem cells and their niches, how this segregation occurs remains elusive. Here we review recent progress on the characterization of niche‐stem cell interactions, with a focus on emerging mechanisms that spatially restrict niche signaling. Mol. Reprod. Dev. 83: 675–683, 2016 © 2016 Wiley Periodicals, Inc.
- Howard Hughes Medical Institute United States
- University of Michigan–Flint United States
- Southwestern University United States
- The University of Texas Southwestern Medical Center United States
- University of Michigan United States
Stem Cells, Obstetrics and Gynecology, Kinesiology and Sports, Social Sciences, Humanities, Health Sciences, Animals, Humans, Public Health, Genitalia, Stem Cell Niche, Women’s and Gender Studies, Signal Transduction
Stem Cells, Obstetrics and Gynecology, Kinesiology and Sports, Social Sciences, Humanities, Health Sciences, Animals, Humans, Public Health, Genitalia, Stem Cell Niche, Women’s and Gender Studies, Signal Transduction
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