Surfactant protein A (SP-A) gene targeted mice
Copyright policy )Surfactant protein A (SP-A) gene targeted mice
Mice lacking surfactant protein A (SP-A) mRNA and protein in vivo were generated using gene targeting techniques. SP-A (-/-) mice have normal levels of SP-B, SP-C and SP-D mRNA and protein and survive and breed normally in vivarium conditions. Phospholipid composition, secretion and clearance, and incorporation of phospholipid precursors are normal in the SP-A (-/-) mice. Lungs of SP-A (-/-) mice have markedly decreased tubular myelin figures and clear Group B streptococci and Pseudomonas aeruginosa less efficiently than SP-A wild type mice. These studies of SP-A (-/-) mice demonstrate that SP-A has an important role in the innate immune system of the lung in vivo.
- Children’s National Health System United States
- Children's Hospital Foundation United States
- Hospital Research Foundation Australia
Pulmonary Surfactant-Associated Proteins, Bacteria, Pulmonary Surfactant-Associated Protein A, Proteolipids, Pulmonary Surfactants, Immunity, Innate, Mice, Mutant Strains, Mice, Phagocytosis, Gene Targeting, Molecular Medicine, Animals, Molecular Biology, Lung, Myelin Sheath
Pulmonary Surfactant-Associated Proteins, Bacteria, Pulmonary Surfactant-Associated Protein A, Proteolipids, Pulmonary Surfactants, Immunity, Innate, Mice, Mutant Strains, Mice, Phagocytosis, Gene Targeting, Molecular Medicine, Animals, Molecular Biology, Lung, Myelin Sheath
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