Mechanisms of transcription-coupled DNA repair
Copyright policy )Mechanisms of transcription-coupled DNA repair
Several types of helix-distorting DNA lesions block the passage of elongating RNA polymerase II. Surprisingly, such transcription-blocking lesions are usually repaired considerably faster than non-obstructive lesions in the non-transcribed strand or in the genome overall. In this review, our knowledge of eukaryotic transcription-coupled repair (TCR) will be considered from the point of view of transcription, and current models for the mechanism of TCR will be discussed.
- University of Cambridge United Kingdom
DNA Repair, Models, Genetic, Transcription, Genetic, Nucleosomes, DNA-Binding Proteins, Gene Expression Regulation, Yeasts, Animals, Humans, RNA Polymerase II, Cockayne Syndrome, DNA Damage
DNA Repair, Models, Genetic, Transcription, Genetic, Nucleosomes, DNA-Binding Proteins, Gene Expression Regulation, Yeasts, Animals, Humans, RNA Polymerase II, Cockayne Syndrome, DNA Damage
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