p53 protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis
Copyright policy )p53 protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis
The tumor suppressor protein p53 is specifically expressed during meiosis in spermatocytes. Subsets of p53 knockout mice exhibit testicular giant cell degenerative syndrome, which suggests p53 may be associated with meiotic cell cycle and/or DNA metabolism. Here, we show that p53 binds to the mouse meiosis-specific RecA-like protein Mus musculus DMC1 (MmDMC1). The C-terminal domain (amino acid 234-340) of MmDMC1 binds to DNA-binding domain of p53 protein. p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells.
- Osaka University Japan
- Osaka Metropolitan University Japan
- Kyoto University Japan
Adenosine Triphosphatases, Mice, Inbred BALB C, Base Sequence, DNA Repair, Nuclear Proteins, Cell Cycle Proteins, Phosphate-Binding Proteins, Cell Line, DNA-Binding Proteins, Meiosis, Mice, Animals, Humans, Tumor Suppressor Protein p53, DNA Primers, Protein Binding
Adenosine Triphosphatases, Mice, Inbred BALB C, Base Sequence, DNA Repair, Nuclear Proteins, Cell Cycle Proteins, Phosphate-Binding Proteins, Cell Line, DNA-Binding Proteins, Meiosis, Mice, Animals, Humans, Tumor Suppressor Protein p53, DNA Primers, Protein Binding
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