Lack of association between childhood stroke after varicella and human leukocyte antigen (HLA)-B51
Copyright policy )Lack of association between childhood stroke after varicella and human leukocyte antigen (HLA)-B51
Human leukocyte antigen (HLA)-B51 has been suggested as an immunogenetic marker for a genetic predisposition to vascular occlusion in response to an immunological stimulus. Varicella has been reported to be a possible risk factor for stroke. We performed DNA-based HLA typing in 11 young patients (mean age: 5.2 years) with unexplained ischaemic stroke. In eight of them varicella had occurred before their stroke. HLA-B51 was negative in all 11 patients and we did not find any significant accumulation of other HLA-subgroups. Our study does not support an association between susceptibility to stroke after varicella and HLA-B51.
Male, Protein S, Stroke, Chickenpox, HLA Antigens, Child, Preschool, Humans, Female, Child, Protein C, Retrospective Studies
Male, Protein S, Stroke, Chickenpox, HLA Antigens, Child, Preschool, Humans, Female, Child, Protein C, Retrospective Studies
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