Comparative Mapping of the Grpr Locus on the X Chromosomes of Man and Mouse
Copyright policy )Comparative Mapping of the Grpr Locus on the X Chromosomes of Man and Mouse
The gastrin-releasing peptide receptor has been previously cloned from both humans and mice. We have mapped the mouse gastrin-releasing peptide receptor (Grpr) locus using a polymorphic CAn repeat located in the 5' untranslated region of the gene and a Mus spretus/Mus musculus interspecific backcross. The Grpr locus mapped between the Pdha-1 and Amg loci on the mouse X chromosome. Studies in man indicate that GRPR maps to the Xp21.2-p22.3 region of the human X chromosome and not to the Xp11-q11 interval as previously reported. The assignment of the GRPR locus to the distal Xp region is supported by the comparative map position in the mouse.
X Chromosome, Base Sequence, Molecular Sequence Data, Chromosome Mapping, Mice, Inbred Strains, Polymerase Chain Reaction, Muridae, Receptors, Bombesin, Mice, Genes, Species Specificity, Animals, Humans, Hybridization, Genetic, Crosses, Genetic, Repetitive Sequences, Nucleic Acid
X Chromosome, Base Sequence, Molecular Sequence Data, Chromosome Mapping, Mice, Inbred Strains, Polymerase Chain Reaction, Muridae, Receptors, Bombesin, Mice, Genes, Species Specificity, Animals, Humans, Hybridization, Genetic, Crosses, Genetic, Repetitive Sequences, Nucleic Acid
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