Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.
Copyright policy )Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.
Mice deficient for the major lysosomal aspartic proteinase cathepsin D, generated by gene targeting, develop normally during the first 2 weeks, stop thriving in the third week and die in a state of anorexia at day 26 +/- 1. An atrophy of the ileal mucosa first observed in the third week progresses towards widespread intestinal necroses accompanied by thromboemboli. Thymus and spleen undergo massive destruction with fulminant loss of T and B cells. Lysosomal bulk proteolysis is maintained. These results suggest, that vital functions of cathepsin D are exerted by limited proteolysis of proteins regulating cell growth and/or tissue homeostasis, while its contribution to bulk proteolysis in lysosomes appears to be non-critical.
- University of Göttingen Germany
Male, B-Lymphocytes, Chimera, Leupeptins, T-Lymphocytes, Thymus Gland, Fibroblasts, Cathepsin D, Specific Pathogen-Free Organisms, Mice, Inbred C57BL, Mice, Ileum, Gene Targeting, Pepstatins, Animals, RNA, Messenger, Atrophy, Intestinal Mucosa, Lysosomes, Spleen
Male, B-Lymphocytes, Chimera, Leupeptins, T-Lymphocytes, Thymus Gland, Fibroblasts, Cathepsin D, Specific Pathogen-Free Organisms, Mice, Inbred C57BL, Mice, Ileum, Gene Targeting, Pepstatins, Animals, RNA, Messenger, Atrophy, Intestinal Mucosa, Lysosomes, Spleen
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).411 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!